Moderation of Anal Sphincter Tone With Nitric Oxide Agonists and Antagonists
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Objective: To test the thesis that agonists and antagonists of nitric oxide, when applied topically to the anal and rectal mucosa, could moderate rectal pressure. Background: In vitro studies of muscle strips have suggested that tension of the internal anal sphincter is controlled by nitric oxide. Methods: Gently restrained, unanesthetized rats were used.
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